Search results for " first episode"
showing 10 items of 13 documents
Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU-GEI study.
2019
Background\ud The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics of psychopathology at First Episode Psychosis (FEP). Regardless of diagnostic categories, we expected that positive symptoms occurred more frequently in ethnic minority groups and in more densely populated environments, and that negative symptoms were associated with indices of neurodevelopmental impairment.\ud \ud Method\ud This study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks st…
Eventi di vita stressanti in un campione di pazienti affetti da psicosi all’esordio: prevalenza, sintomatologia ed età d’esordio
2011
Introduzione: Un consistente numero di studi suggerisce un’elevata prevalenza di eventi traumatici nella storia di soggetti con disturbi psicotici (Shevlin et al, 2008). Piu’ che l’impatto di un singolo evento di vita stressante, l’esposizione cumulativa ad esperienze traumatiche sembra incrementare il rischio di psicosi (van Winkel et al, 2008). Scopo dello studio e’ valutare la prevalenza di tali eventi in soggetti al primo episodio psicotico a confronto con controlli sani e la possibile correlazione con la sintomatologia psicotica e l’età di esordio. Metodologia: In atto sono stati reclutati 74 soggetti al primo episodio psicotico (51 m, 23 f; em=26.39, ds=9.36) e 27 controlli sani (18 m…
Prevalence of bullying victimisation amongst first-episode psychosis patients and unaffected controls
2013
Background—Despite increasing evidence suggesting that childhood maltreatment is significantly associated with psychosis, the specific role of bullying in the onset of psychotic disorders is still unclear. This study aimed to examine whether bullying was more prevalent amongst individuals presenting to services for the first time with a psychotic disorder than in unaffected community controls. Methods—Data on exposure to bullying, psychotic symptoms, cannabis use and history of conduct disorder were collected cross-sectionally from 222 first-presentation psychosis cases and 215 geographically-matched controls. Bullying victimisation was assessed retrospectively as part of the Brief Life Eve…
Traumi infantili in un campione di pazienti affetti da psicosi all’esordio: associazione con psicopatologia e funzioni cognitive. Risultati prelimina…
2011
Introduzione: Numerosi studi hanno evidenziato l’associazione tra traumi infantili e psicosi (Morgan, Fisher, 2007). Sebbene inizialmente fosse enfatizzato il ruolo dell’abuso sessuale, recentemente l’associazione con l’abuso fisico e’ stata riportata come piu’ forte (Fisher et al, 2010; Rubino et al, 2009). Scopi dello studio sono valutare la prevalenza di eventi avversi infantili in un campione di soggetti al primo episodio psicotico e la sua relazione con la psicopatologia e le funzioni cognitive. Metodologia: Sono stati reclutati 74 soggetti al primo episodio psicotico (51 m, 23 f; em=26.39, ds=9.36). Sono state somministrate le seguenti interviste e test: CECA-Q (Bifulco et al, 2005) p…
Cannabis users have higher premorbid IQ than other patients with first onset psychosis.
2013
Background: A number of studies have reported that patients with psychosis who use cannabis have better cognitive performance than those who do not. This is surprising as cannabis can impair cognition in healthy subjects. An obvious question is whether the better current performance of psychotic patients who have used cannabis is a reflection of their having a higher premorbid IQ than those psychotic patients who haven't used cannabis. Aim: In a sample of patients at their first episode of psychosis, we tested the hypothesis that patients who smoked cannabis would have a higher premorbid IQ than patients who did not. Methodology: 279 participants (119 patients and 160 healthy controls) were…
Substance use, medication adherence and outcome one year following a first episode of psychosis
2016
Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset signific…
Does clinical or cognitive insight predict outcome in psychosis? Findings from a longitudinal first episode cohort
2013
Influence of social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis
2019
This work was supported by the Carlos III Institute of Health and European Fund for Regional Development (PI08/1213, PI11/01977, PI14/01900, PI08/01026, PI11/02831, PI14/01621, PI08/1161, PI16/00359, PI16/01164, PI18/00805), the Basque Foundation for Health Innovation and Research (BIOEF), the Secretaria d´Universitats I Recerca del Departament d´Economia I Coneixement (2017 SGR 1365), and R&D activities in Biomedicine, Madrid Regional Government and Structural Funds of the European Union (S2017/BMD-3740 (AGES-CM 2-CM)).
Differences in cannabis-related experiences between patients with a first episode of psychosis and controls
2016
BackgroundMany studies have reported that cannabis use increases the risk of a first episode of psychosis (FEP). However, only a few studies have investigated the nature of cannabis-related experiences in FEP patients, and none has examined whether these experiences are similar in FEP and general populations. The aim of this study was to explore differences in self-reported cannabis experiences between FEP and non-psychotic populations.MethodA total of 252 subjects, who met International Classification of Diseases (ICD)-10 criteria for FEP, and 217 controls who reported cannabis use were selected from the Genetics and Psychosis (GAP) study. The Medical Research Council Social Schedule and t…
Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia
2022
The EU-GEI Project was funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). The Brazilian study was funded by the Säo Paulo Research Foundation under grant number 2012/0417-0.